פיד הקבוצות

Dear Friends

We’re excited to share with you our special group offers at Orient Restaurant, located in Beit Sahour – Shepherds Field.

It would be our pleasure to welcome your group and provide an unforgettable dining experience. We look forward to the opportunity of working together.

For more information, feel free to contact us anytime.

📞 Phone: 052-4069352

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited kidney disorder, characterized by the progressive development and enlargement of fluid-filled cysts within the renal parenchyma, ultimately leading to the destruction of normal kidney tissue, a decline in glomerular filtration rate, and end-stage renal disease (ESRD).

The disease is primarily caused by mutations in the PKD1 or PKD2 genes, which encode polycystin-1 and polycystin-2, respectively, leading to abnormalities in tubular epithelial cell function, including uncontrolled proliferation, abnormal fluid secretion, and a vicious cycle of cyst expansion under the influence of growth-promoting hormones.

Historically, treatment for ADPKD focused predominantly on supportive care, including rigorous blood pressure control (often with ACE inhibitors or ARBs) and managing complications such as pain, cyst infection, and hematuria. However, the therapeutic landscape was transformed by the introduction of agents that target the molecular drivers of cystogenesis. A key pathological pathway involves the activation of the…